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Nature Immunology 8, 1287 - 1289 (2007)
doi:10.1038/ni1207-1287
Macrophage tolerance: CD47–SIRP-
–mediated signals matter
Hitoshi Takizawa1 & Markus G Manz2
- Hitoshi Takizawa is with the Institute for Research in Biomedicine, CH-6500 Bellinzona, Switzerland.
- Markus G. Manz is with the Institute for Research in Biomedicine and the Department of Hematology, Oncology Institute of Southern Switzerland, Ospedale San Giovanni, CH-6500 Bellinzona, Switzerland. e-mail: manz@irb.unisi.ch
Abstract
Inhibition of phagocyte activity depends on the ligation of SIRP-
by CD47. New findings show that Sirpa polymorphisms influence the engraftment and tolerance of xenogeneic transplants in NOD-SCID mice.
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