News and Views

Nature Immunology 8, 1201 - 1203 (2007)
doi:10.1038/ni1107-1201

Inhibitory receptors: whose side are they on?

Alison Crawford1 & E John Wherry1

  1. Alison Crawford and E. John Wherry are with the Immunology Program, The Wistar Institute, Philadelphia, Pennsylvania 19104, USA e-mail: jwherry@wistar.org

A new study demonstrates involvement of the inhibitory receptor CTLA-4 in T cell exhaustion during infection with human immunodeficiency virus, adding complexity and diversity to the inhibitory pathways regulating T cell responses during chronic viral infections in humans.

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