Article abstract
Nature Immunology 8, 1060 - 1066 (2007)
Published online: 2 September 2007 | doi:10.1038/ni1505
Minimal activation of memory CD8+ T cell by tissue-derived dendritic cells favors the stimulation of naive CD8+ T cells
Gabrielle T Belz1, Sammy Bedoui1, Fiona Kupresanin1, Francis R Carbone2 & William R Heath1
Abstract
Of the many dendritic cell (DC) subsets, DCs expressing the monomorphic coreceptor CD8 
-chain (CD8) are localized permanently in lymphoid organs, whereas 'tissue-derived DCs' remain in nonlymphoid tissues until they 'capture' antigen and then move to local lymph nodes. Here we show that after lung infection, both naive and memory CD8+ 'killer' T cells responded to influenza virus antigens presented by lymph node–resident CD8+ DCs, but only naive cells responded to antigens presented by lung-derived DCs. This difference provides a mechanism for priming naive T cell responses in conditions in which robust memory predominates. Our findings have implications for immunity to pathogens that can mutate their T cell epitopes, such as influenza virus and human immunodeficiency virus, and challenge the long-held view that memory T cells have less-stringent requirements for activation than naive T cells have.
- Immunology Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia.
- Department of Microbiology and Immunology, The University of Melbourne, Melbourne, Victoria 3010, Australia.
Correspondence to: Gabrielle T Belz1 e-mail: belz@wehi.edu.au
Correspondence to: William R Heath1 e-mail: heath@wehi.edu.au
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