News and Views
Nature Immunology 8, 1035 - 1037 (2007)
doi:10.1038/ni1007-1035
A catch to integrin activation
- Rodger P. McEver is with the Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104, USA. e-mail: rodger-mcever@omrf.org
- Cheng Zhu is in the Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332, USA.
Abstract
T cells interact with chemokines displayed on cells outside and inside blood vessels of the lymph node. New work shows that these chemokines exert distinct activation effects on T cell integrins depending on their mechanical environment.
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