News and Views


Nature Immunology 8, 1035 - 1037 (2007)
doi:10.1038/ni1007-1035

A catch to integrin activation

Rodger P McEver1 & Cheng Zhu2

  1. Rodger P. McEver is with the Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104, USA. e-mail: rodger-mcever@omrf.org
  2. Cheng Zhu is in the Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332, USA.


T cells interact with chemokines displayed on cells outside and inside blood vessels of the lymph node. New work shows that these chemokines exert distinct activation effects on T cell integrins depending on their mechanical environment.

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