News and Views
Nature Immunology 8, 1033 - 1035 (2007)
doi:10.1038/ni1007-1033
T cell receptors get back to basics
E Yvonne Jones1, Mariolina Salio2 & Vincenzo Cerundolo2
- E. Yvonne Jones is with the Cancer Research UK Receptor Structure Research Group, The Henry Wellcome Building for Genomic Medicine, Oxford OX3 7BN, UK. e-mail: yvonne@strubi.ox.ac.uk
- Mariolina Salio and Vincenzo Cerundolo are with the Cancer Research UK Tumor Immunology Group, The Weatherall Institute of Molecular Medicine, Nuffield Department of Medicine, University of Oxford, Oxford OX3 9DS, UK. e-mail: vincenzo.cerundolo@imm.ox.ac.uk
Abstract
For both mice and humans, an invariant T cell receptor mediates the recognition of glycolipid antigens presented in the context of CD1d molecules. Crystal structure and mutagenesis-based analyses now identify a minimalist binding mode well suited to an 'innate-style' pattern-recognition function.
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