Supplementary information
From the following article
Eun Mi Hur, Sawsan Youssef, M Edward Haws, Susan Y Zhang, Raymond A Sobel & Lawrence Steinman
Nature Immunology 8, 74 - 83 (2007) Published online: 3 December 2006
doi:10.1038/ni1415
Supplementary Fig. 1
Autoimmune optic neuritis induced by OPN in MOG-specific TCR transgenic mice with EAE.
Supplementary Fig. 2
Residual LPS in purified OPN does not affect clinical score of EAE.
Supplementary Fig. 3
Increased T cell proliferation by OPN.
Supplementary Fig. 4
The time course expression of Bim, Bak and Bax after T cell activation in vitro.
Supplementary Fig. 5
OPN does not affect Fas-induced cell death.
Supplementary Fig. 6
OPN inhibits nuclear translocation of AIF.
Supplementary Fig. 7
Schematic diagram of OPN-induced survival of T cell.
Supplementary Fig. 8
Schematic diagram of the suggested model for autoimmune relapse.
Supplementary Table 1
EAE induced in OPN-KO and OPN-WT mice.
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