A matter of debate - p1

doi:10.1038/ni0107-1

Abstract - A matter of debate | Full Text - A matter of debate | PDF (72 KB) - A matter of debate

Organ-specific regulation of innate immunity - pp3 - 4

Eyal Raz

doi:10.1038/ni0107-3

Full Text - Organ-specific regulation of innate immunity | PDF (90 KB) - Organ-specific regulation of innate immunity

Conceptualizing immune responsiveness - pp5 - 7

Neil S Greenspan

doi:10.1038/ni0107-5

Full Text - Conceptualizing immune responsiveness | PDF (125 KB) - Conceptualizing immune responsiveness

On observing and analyzing disease versus signals - pp8 - 10

Rolf Zinkernagel

doi:10.1038/ni0107-8

Full Text - On observing and analyzing disease versus signals | PDF (137 KB) - On observing and analyzing disease versus signals

Friendly and dangerous signals: is the tissue in control? - pp11 - 13

Polly Matzinger

doi:10.1038/ni0107-11

Full Text - Friendly and dangerous signals: is the tissue in control? | PDF (124 KB) - Friendly and dangerous signals: is the tissue in control?

Shigella rewrites host transcriptional responses - pp15 - 16

Guntram A Grassl & B Brett Finlay

doi:10.1038/ni0107-15

Full Text - Shigella rewrites host transcriptional responses | PDF (1,585 KB) - Shigella rewrites host transcriptional responses

See also: Article by Arbibe et al.

DEteCTINg fungal pathogens - pp17 - 18

Catherine Dostert & Jürg Tschopp

doi:10.1038/ni0107-17

Full Text - DEteCTINg fungal pathogens | PDF (414 KB) - DEteCTINg fungal pathogens

See also: Article by Taylor et al. | Article by Saijo et al.

Osteopontin-induced survival of T cells - pp19 - 20

Ingunn M Stromnes & Joan M Goverman

doi:10.1038/ni0107-19

Full Text - Osteopontin-induced survival of T cells | PDF (353 KB) - Osteopontin-induced survival of T cells

See also: Article by Hur et al.

Trimming creates a new self-image - pp21 - 22

Julio C Delgado & Peter E Jensen

doi:10.1038/ni0107-21

Full Text - Trimming creates a new self-image | PDF (378 KB) - Trimming creates a new self-image

See also: Article by Hammer et al.

Research Highlights - p23

doi:10.1038/ni0107-23

Full Text - Research Highlights | PDF (43 KB) - Research Highlights

T cell–directed therapies: lessons learned and future prospects - pp25 - 30

Eric H Liu, Richard M Siegel, David M Harlan & John J O'Shea

doi:10.1038/ni1429

Abstract - T cell-directed therapies: lessons learned and future prospects | Full Text - T cell–directed therapies: lessons learned and future prospects | PDF (247 KB) - T cell–directed therapies: lessons learned and future prospects

Dectin-1 is required for -glucan recognition and control of fungal infection - pp31 - 38

Philip R Taylor, S Vicky Tsoni, Janet A Willment, Kevin M Dennehy, Marcela Rosas, Helen Findon, Ken Haynes, Chad Steele, Marina Botto, Siamon Gordon & Gordon D Brown

doi:10.1038/ni1408

Abstract - Dectin-1 is required for [beta]-glucan recognition and control of fungal infection | Full Text - Dectin-1 is required for -glucan recognition and control of fungal infection | PDF (474 KB) - Dectin-1 is required for -glucan recognition and control of fungal infection | Supplementary information

See also: News and Views by Dostert & Tschopp | Article by Saijo et al.

Dectin-1 is required for host defense against Pneumocystis carinii but not against Candida albicans - pp39 - 46

Shinobu Saijo, Noriyuki Fujikado, Takahisa Furuta, Soo-hyun Chung, Hayato Kotaki, Keisuke Seki, Katsuko Sudo, Shizuo Akira, Yoshiyuki Adachi, Naohito Ohno, Takeshi Kinjo, Kiwamu Nakamura, Kazuyoshi Kawakami & Yoichiro Iwakura

doi:10.1038/ni1425

Abstract - Dectin-1 is required for host defense against Pneumocystis carinii but not against Candida albicans | Full Text - Dectin-1 is required for host defense against Pneumocystis carinii but not against Candida albicans | PDF (387 KB) - Dectin-1 is required for host defense against Pneumocystis carinii but not against Candida albicans | Supplementary information

See also: News and Views by Dostert & Tschopp | Article by Taylor et al.

An injected bacterial effector targets chromatin access for transcription factor NF-B to alter transcription of host genes involved in immune responses - pp47 - 56

Laurence Arbibe, Dong Wook Kim, Eric Batsche, Thierry Pedron, Bogdan Mateescu, Christian Muchardt, Claude Parsot & Philippe J Sansonetti

doi:10.1038/ni1423

Abstract - An injected bacterial effector targets chromatin access for transcription factor NF-[kappa]B to alter transcription of host genes involved in immune responses | Full Text - An injected bacterial effector targets chromatin access for transcription factor NF-B to alter transcription of host genes involved in immune responses | PDF (624 KB) - An injected bacterial effector targets chromatin access for transcription factor NF-B to alter transcription of host genes involved in immune responses | Supplementary information

See also: News and Views by Grassl & Finlay

Kinase MEKK1 is required for CD40-dependent activation of the kinases Jnk and p38, germinal center formation, B cell proliferation and antibody production - pp57 - 63

Ewen Gallagher, Thomas Enzler, Atsushi Matsuzawa, Amy Anzelon-Mills, Dennis Otero, Ryan Holzer, Edith Janssen, Min Gao & Michael Karin

doi:10.1038/ni1421

Abstract - Kinase MEKK1 is required for CD40-dependent activation of the kinases Jnk and p38, germinal center formation, B cell proliferation and antibody production | Full Text - Kinase MEKK1 is required for CD40-dependent activation of the kinases Jnk and p38, germinal center formation, B cell proliferation and antibody production | PDF (422 KB) - Kinase MEKK1 is required for CD40-dependent activation of the kinases Jnk and p38, germinal center formation, B cell proliferation and antibody production | Supplementary information

The kinases aurora B and mTOR regulate the G1–S cell cycle progression of T lymphocytes - pp64 - 73

Jianxun Song, Shahram Salek-Ardakani, Takanori So & Michael Croft

doi:10.1038/ni1413

Abstract - The kinases aurora B and mTOR regulate the G1-S cell cycle progression of T lymphocytes | Full Text - The kinases aurora B and mTOR regulate the G1–S cell cycle progression of T lymphocytes | PDF (614 KB) - The kinases aurora B and mTOR regulate the G1–S cell cycle progression of T lymphocytes | Supplementary information

Osteopontin-induced relapse and progression of autoimmune brain disease through enhanced survival of activated T cells - pp74 - 83

Eun Mi Hur, Sawsan Youssef, M Edward Haws, Susan Y Zhang, Raymond A Sobel & Lawrence Steinman

doi:10.1038/ni1415

Abstract - Osteopontin-induced relapse and progression of autoimmune brain disease through enhanced survival of activated T cells | Full Text - Osteopontin-induced relapse and progression of autoimmune brain disease through enhanced survival of activated T cells | PDF (507 KB) - Osteopontin-induced relapse and progression of autoimmune brain disease through enhanced survival of activated T cells | Supplementary information

See also: News and Views by Stromnes & Goverman

Hematopoietic progenitor kinase 1 negatively regulates T cell receptor signaling and T cell–mediated immune responses - pp84 - 91

Jr-Wen Shui, Jonathan S Boomer, Jin Han, Jun Xu, Gregory A Dement, Guisheng Zhou & Tse-Hua Tan

doi:10.1038/ni1416

Abstract - Hematopoietic progenitor kinase 1 negatively regulates T cell receptor signaling and T cell-mediated immune responses | Full Text - Hematopoietic progenitor kinase 1 negatively regulates T cell receptor signaling and T cell–mediated immune responses | PDF (379 KB) - Hematopoietic progenitor kinase 1 negatively regulates T cell receptor signaling and T cell–mediated immune responses | Supplementary information

HLA-DM targets the hydrogen bond between the histidine at position 81 and peptide to dissociate HLA-DR–peptide complexes - pp92 - 100

Kedar Narayan, Chih-Ling Chou, AeRyon Kim, Isamu Z Hartman, Sarat Dalai, Stanislav Khoruzhenko & Scheherazade Sadegh-Nasseri

doi:10.1038/ni1414

Abstract - HLA-DM targets the hydrogen bond between the histidine at position [beta]81 and peptide to dissociate HLA-DR-peptide complexes | Full Text - HLA-DM targets the hydrogen bond between the histidine at position 81 and peptide to dissociate HLA-DR–peptide complexes | PDF (351 KB) - HLA-DM targets the hydrogen bond between the histidine at position 81 and peptide to dissociate HLA-DR–peptide complexes | Supplementary information

In the absence of aminopeptidase ERAAP, MHC class I molecules present many unstable and highly immunogenic peptides - pp101 - 108

Gianna Elena Hammer, Federico Gonzalez, Edward James, Hector Nolla & Nilabh Shastri

doi:10.1038/ni1409

Abstract - In the absence of aminopeptidase ERAAP, MHC class I molecules present many unstable and highly immunogenic peptides | Full Text - In the absence of aminopeptidase ERAAP, MHC class I molecules present many unstable and highly immunogenic peptides | PDF (1,921 KB) - In the absence of aminopeptidase ERAAP, MHC class I molecules present many unstable and highly immunogenic peptides | Supplementary information

See also: News and Views by Delgado & Jensen