News and Views
Nature Immunology 8, 21 - 22 (2007)
doi:10.1038/ni0107-21
Trimming creates a new self-image
Julio C Delgado1 & Peter E Jensen1
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Julio C. Delgado and Peter E. Jensen are in the Department of Pathology, University of Utah, Salt Lake City, Utah 84112, USA
e-mail: julio.delgado@path.utah.edu or e-mail: peter.jensen@path.utah.edu
Abstract
Loss of the aminopeptidase ERAAP produces a distinct repertoire of peptide–major histocompatibility complex class I complexes. That difference elicits frequencies of immune recognition in congenic mice similar to those in allogeneic immune responses.

