1. Guntram A. Grassl is in the Michael Smith Laboratories and B. Brett Finlay is in the Michael Smith Laboratories and the Department of Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada.
   e-mail: bfinlay@interchange.ubc.ca

Abstract

Histone modification is an important means of 'fine tuning' gene expression. The Shigella flexneri dually specific phosphatase OspF shapes host inflammatory transcriptional responses by inducing epigenetic modifications.

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