Commentary
Nature Immunology 8, 11 - 13 (2007)
doi:10.1038/ni0107-11
Friendly and dangerous signals: is the tissue in control?
Polly Matzinger1
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Polly Matzinger is with The Ghost Lab, Laboratory of Cellular and Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.
e-mail: pcm@helix.nih.gov
Abstract
In their own defense, tissues send a panoply of signals that initiate immunity and guide the choice of effector class. TH1-TH2 and Treg is far too simple a representation of the breathtaking variety of the resulting responses.
