All in the family: IL-27 suppression of TH-17 cells
John Colgan & Paul Rothman
John Colgan and Paul Rothman are in the Department of Internal Medicine, University of Iowa, Iowa City, Iowa 52242, USA. paul-rothman@uiowa.edu
Interleukin 17 (IL-17)–producing T cells are associated with inflammatory conditions. Two studies now show that IL-27, an IL-12 family member with both pro- and anti-inflammatory properties, potently suppresses the development of IL-17-producing T cells.
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