Nature Immunology 7, 851 - 858 (2006)
Published online: 25 June 2006; | doi:10.1038/ni1355
The kinase TAK1 integrates antigen and cytokine receptor signaling for T cell development, survival and functionYisong Y Wan, Hongbo Chi, Min Xie, Michael D Schneider&
Richard A Flavell Supplementary Fig. 1 (pdf 68K)
Phenotypic analysis of DP and CD4 SP thymocytes. Supplementary Fig. 2 (pdf 28K)
Surface expression of IL-7R is not altered on TAK1 deficient cells. Supplementary Fig. 3 (pdf 36K)
TAK1 deficiency results in accelerated T cell apoptosis in the long-term culture. Supplementary Fig. 4 (pdf 52K)
TAK1-deficient effector T cells compete poorly with wild-type counterparts in response to cytokine stimulation. Supplementary Fig. 5 (pdf 20K)
The numbers of cells recovered at the end of [3H]thymidine incorporation are comparable between TAK1 intact and deficient effector T cells. Supplementary Fig. 6 (pdf 32K)
TAK1 deletion did not affect the expression of CD25, IL-7R or IL-15R on effector T cells. Supplementary Fig. 7 (pdf 88K)
TAK1 is essential for the constitutive p38 activity in thymocytes.
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