Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Viral evasion of antigen presentation: not just for peptides anymore

Viruses have evolved several strategies to subvert host defenses. New evidence indicates that herpes simplex virus 1 prevents glycolipid antigen presentation to natural killer T cells by downregulating CD1d expression.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Trafficking pathway of human CD1d molecules and points of interference by viruses.

Kim Caesar

References

  1. Tortorella, D., Gewurz, B.E., Furman, M.H., Schust, D.J. & Ploegh, H.L. Annu. Rev. Immunol. 18, 861–926 (2000).

    Article  CAS  Google Scholar 

  2. Yuan, W., Dasgupta, A. & Cresswell, P. Nat. Immunol. 7, 835–842 (2006).

    Article  CAS  Google Scholar 

  3. Brigl, M. & Brenner, M.B. Annu. Rev. Immunol. 22, 817–890 (2004).

    Article  CAS  Google Scholar 

  4. Skold, M. & Behar, S.M. Infect. Immun. 71, 5447–5455 (2003).

    Article  Google Scholar 

  5. Sanchez, D.J., Gumperz, J.E. & Ganem, D. J. Clin. Invest. 115, 1369–1378 (2005).

    Article  CAS  Google Scholar 

  6. Cho, S. et al. Virology 337, 242–252 (2005).

    Article  CAS  Google Scholar 

  7. Renukaradhya, G.J. et al. J. Immunol. 175, 4301–4308 (2005).

    Article  CAS  Google Scholar 

  8. Joyce, S. & Van Kaer, L. Curr. Opin. Immunol. 15, 95–104 (2003).

    Article  CAS  Google Scholar 

  9. Chen, N. et al. Eur. J. Immunol. 36, 278–286 (2006).

    Article  CAS  Google Scholar 

  10. Grubor-Bauk, B., Simmons, A., Mayrhofer, G. & Speck, P.G. J. Immunol. 170, 1430–1434 (2003).

    Article  CAS  Google Scholar 

  11. Levy, O. et al. J. Infect. Dis. 188, 948–953 (2003).

    Article  Google Scholar 

  12. Van Kaer, L. & Joyce, S. Curr. Biol. 15, R429–R431 (2005).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Van Kaer, L., Joyce, S. Viral evasion of antigen presentation: not just for peptides anymore. Nat Immunol 7, 795–797 (2006). https://doi.org/10.1038/ni0806-795

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/ni0806-795

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing