Nature Immunology 7, 709 - 714 (2006)
Published online: 19 June 2006; | doi:10.1038/ni1360
Thymic stromal lymphopoietin in normal and pathogenic T cell development and functionSteven F Ziegler1
& Yong-Jun Liu21
Immunology Program, Benaroya Research Institute, Seattle, Washington 98101, USA. 2
Department of Immunology and Center of Cancer Immunology Research, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
Correspondence should be addressed to Steven F Ziegler sziegler@benaroyaresearch.org or Yong-Jun Liu yjliu@mdanderson.org Thymic stromal lymphopoietin, a four helix–bundle cytokine, is expressed mainly by barrier epithelial cells and is a potent activator of several cell types, particularly myeloid dendritic cells. TSLP influences the outcome of interactions between dendritic cells and CD4+ thymocytes and T cells in many situations, such as the regulation of the positive selection of regulatory T cells, maintenance of peripheral CD4+ T cell homeostasis and induction of CD4+ T cell–mediated allergic inflammation.
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