IRF4 – a factor for class switching and antibody secretion
Simon Fillatreau
& Andreas Radbruch
Simon Fillatreau and Andreas Radbruch are with Deutsches Rheuma-Forschungszentrum, Berlin 10117, Germany. radbruch@drfz.de
Cognate antigen triggers B cells to undergo antibody maturation and terminal differentiation into antibody-secreting plasma cells. The transcription factor IRF4, which is essential for early B cell development, is also influential at these later stages of B cell development and function.
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
