Nature Immunology 7, 692 - 697 (2006)
doi:10.1038/ni0706-692
Pursuing gene regulation 'logic' via RNA interference and chromatin immunoprecipitationCaiyi C Li, Vladimir R Ramirez-Carrozzi
& Stephen T Smale
Caiyi C. Li, Vladimir R. Ramirez-Carrozzi and Stephen T. Smale are with the Howard Hughes Medical Institute and Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine at UCLA, Los Angeles, California 90095-1662, USA. smale@mednet.ucla.edu
RNA interference and chromatin immunoprecipitation are now firmly established as useful methods for studying mechanisms of gene regulation in vivo. Their combined use can help elucidate gene regulation 'logic' by aiding in target gene identification for transcription factors and chromatin-modifying complexes.
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