Nature Immunology 7, 555 - 557 (2006)
doi:10.1038/ni0606-555
Pin-ning down immune responses to RNA virusesNadege Goutagny, Martina Severa
& Katherine A Fitzgerald
Nadege Goutagny, Martina Severa and Katherine A. Fitzgerald are in the Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA. kate.fitzgerald@umassmed.edu
To prevent RNA virus–dependent tissue damage caused by interferon-regulatory factor 3 (IRF3)–induced type I interferons, proteasome-dependent destruction of IRF3 is orchestrated by the cytoplasmic prolyl isomerase Pin1.
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