Nature Immunology 7, 489 - 497 (2006)
Published online: 2 April 2006; | doi:10.1038/ni1324
A unique function for cyclin D3 in early B cell developmentA Byron Cooper1, 3, Catherine M Sawai1, 3, Ewa Sicinska2, Sarah E Powers1, Piotr Sicinski2, Marcus R Clark1, 3
& Iannis Aifantis1, 31
Department of Medicine, Section of Rheumatology, University of Chicago, Chicago, Illinois 60637, USA. 2
Department of Cancer Biology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 62115, USA. 3
These authors contributed equally to this work.
Correspondence should be addressed to Iannis Aifantis iaifanti@medicine.bsd.uchicago.edu or Marcus R Clark mclark@medicine.bsd.uchicago.edu During hematopoiesis, stem cell proliferation is dependent on expression of the D-type cyclins. However, little is known about how each cyclin D contributes to the development of specific hematopoietic lineages. Here, analysis of Ccnd1-/-, Ccnd2-/-, Ccnd3-/- and Ccnd2-/-Ccnd3-/- mice showed that cyclin D3 was uniquely required for the development of pre–B cells. Transcription of Ccnd3 was dependent on expression of the common  -chain. In contrast, expression of the pre–B cell receptor and activation of 'downstream' signaling pathways prevented proteasome-mediated degradation of cyclin D3. Cyclin D3 has a key function in B cell development by integrating cytokine and pre–B cell receptor–dependent signals to expand the pool of pre–B cells that have successfully rearranged immunoglobulin heavy chain.
MORE ARTICLES LIKE THIS These links to content published by NPG are automatically generated.
|
