Nature Immunology 7, 441 - 443 (2006)
doi:10.1038/ni0506-441
Opn: key regulator of pDC interferon productionWei Cao
& Yong-Jun Liu
Wei Cao and Yong-Jun Liu are in the Department of Immunology, University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030, USA. wcao@mdacc.tmc.edu or yjliu@mdanderson.org
Plasmacytoid dendritic cells selectively express Toll-like receptors 7 and 9 and respond to virus infection by triggering massive interferon production, a pathway regulated by osteopontin expressed in plasmacytoid dendritic cells.
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