Neil Lineberry and C. Garrison Fathman are in the Department of Medicine, Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, California 94305, USA. cfathman@stanford.edu
Deubiquitinating enzymes remove polyubiquitin chains from and alter the fate of specific target proteins. The CYLD deubiquitinating enzyme regulates proximal T cell receptor signaling in thymocytes by selectively binding to and deubiquitinating the active form of the kinase Lck.
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