Nature Immunology 7, 311 - 317 (2006)
Published online: 5 February 2006; | doi:10.1038/ni1309
Monocyte emigration from bone marrow during bacterial infection requires signals mediated by chemokine receptor CCR2Natalya V Serbina
& Eric G Pamer
Infectious Disease Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, Immunology Program, Sloan-Kettering Institute, New York, New York 10021, USA.
Correspondence should be addressed to Natalya V Serbina serbinan@mskcc.org Monocytes recruited to tissues mediate defense against microbes or contribute to inflammatory diseases. Regulation of the number of circulating monocytes thus has implications for disease pathogenesis. However, the mechanisms controlling monocyte emigration from the bone marrow niche where they are generated remain undefined. We demonstrate here that the chemokine receptor CCR2 was required for emigration of Ly6Chi monocytes from bone marrow. Ccr2-/- mice had fewer circulating Ly6Chi monocytes and, after infection with Listeria monocytogenes, accumulated activated monocytes in bone marrow. In blood, Ccr2-/- monocytes could traffic to sites of infection, demonstrating that CCR2 is not required for migration from the circulation into tissues. Thus, CCR2-mediated signals in bone marrow determine the frequency of Ly6Chi monocytes in the circulation.
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