B. Matija Peterlin is in the Department of Medicine, Microbiology and Immunology, University of California, San Francisco, California 94143-0703, USA. matija@itsa.ucsf.edu
Lentiviral Nef protein has many functions in the evasion of host immune defenses. Another 'chink' in the host immune 'armor' has now been exposed by Nef's ability to inhibit immunoglobulin class switching.
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