Nature Immunology 7, 227 - 228 (2006)
doi:10.1038/ni0306-227
PD-1 blockade: rescue from a near-death experienceJoseph N Blattman
& Philip D Greenberg
Joseph N. Blattman and Philip D. Greenberg are in the Department of Immunology, University of Washington, Seattle, Washington 98195-6527, USA, and the Program in Immunology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109-1024, USA. pgreen@u.washington.edu
It is unclear whether T cell exhaustion is reversible. A recent Nature paper shows that in vivo blockade of the inhibitory molecule PD-1 can restore the function of exhausted CD8+ T cells during chronic viral infection.
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