Leonore A. Herzenberg and James W. Tung are in the Department of Genetics, Stanford University School of Medicine, Stanford, California 94305-5318, USA. leeherz@stanford.edu
Functional and phenotypic distinctions characterize B-1 cells versus B-2 cells. The identification of adult bone marrow cells that give rise exclusively to B-1 B cells support earlier ideas regarding the existence of dedicated B-1 progenitors.
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