Robert W. Carter and David F. Tough are with The Edward Jenner Institute for Vaccine Research, Compton, Newbury, Berkshire RG20 7NN, UK. david.tough@jenner.ac.uk
'Forward' genetic approaches for elucidating function can lead to unexpected findings. A single missense mutation is found to disrupt both antigen presentation and nucleic acid Toll-like receptor signaling, two processes involving endocytic pathways.
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