Youth has its privileges: maturation inhibits DC cross-priming
Heather D Hickman-Miller
& Jonathan W Yewdell
Heather D. Hickman-Miller and Jonathan W. Yewdell are in the Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892-0440, USA. jyewdell@nih.gov
Naive CD8+ T cells can be activated via dendritic cell 'cross-priming' of antigens obtained exogenously. Dendritic cells cannot cross-prime, however, after systemic activation in vivo, potentially contributing to immunosuppression associated with severe infections.
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