Nature Immunology
- 7, 1258 - 1265 (2006)
doi:10.1038/ni1417
Myeloid C-type lectins in innate immunityMatthew J Robinson, David Sancho, Emma C Slack, Salomé LeibundGut-Landmann & Caetano Reis e Sousa
Immunobiology Laboratory, Cancer Research UK, London Research Institute, London WC2A 3PX, United Kingdom.
Correspondence should be addressed to Caetano Reis e Sousa caetano@cancer.org.uk C-type lectins expressed on myeloid cells comprise a family of proteins that share a common structural motif, and some act as receptors in pathogen recognition. But just as the presence of leucine-rich repeats alone is not sufficient to define a Toll-like receptor, the characterization of C-type lectin receptors in innate immunity requires the identification of accompanying signaling motifs. Here we focus on the known signaling pathways of myeloid C-type lectins and on their possible functions as autonomous activating or inhibitory receptors involved in innate responses to pathogens or self.
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