Nature Immunology
- 7, 1250 - 1257 (2006)
Published online: 16 November 2006; | doi:10.1038/ni1412
Nod-like proteins in immunity, inflammation and diseaseJörg H Fritz1, Richard L Ferrero2, Dana J Philpott1 & Stephen E Girardin31
Department of Immunology, Medical Sciences Building, University of Toronto, Toronto, Ontario M5S 1A8, Canada. 2
Department of Microbiology, Monash University, Clayton, 3800 Victoria, Australia. 3
Department of Laboratory Medicine and Pathobiology, Medical Sciences Building, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
Correspondence should be addressed to dana.philpott@utoronto.ca The intracellular Nod-like proteins or receptors are a family of sensors of intracellularly encountered microbial motifs and 'danger signals' that have emerged as being critical components of the innate immune responses and of inflammation in mammals. Several Nod-like receptors, including Nod1, Nod2, NALP3, Ipaf and Naip, are strongly associated with host responses to intracellular invasion by bacteria or the intracellular presence of specific bacterial products. An additional key function of Nod-like receptors is in inflammatory conditions, which has been emphasized by the identification of several different mutations in the genes encoding Nod1, Nod2 and NALP3 that are associated with susceptibility to inflammatory disorders. Those and other issues related to the Nod-like receptor family are discussed here.
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