Nature Immunology
- 7, 1266 - 1273 (2006)
Published online: 16 November 2006; | doi:10.1038/ni1411
The TREM receptor family and signal integrationJulia Klesney-Tait, Isaiah R Turnbull & Marco Colonna
Washington University School of Medicine, Department of Pathology and Immunology, Saint Louis, Missouri 63110, USA.
Correspondence should be addressed to Marco Colonna mcolonna@pathology.wustl.edu TREM proteins are a family of cell surface receptors that participate in diverse cell processes, including inflammation, bone homeostasis, neurological development and coagulation. TREM-1, the first to be identified, acts to amplify inflammation. Other TREM proteins regulate the differentiation and function of macrophages, microglia, dendritic cells, osteoclasts and platelets. Here we discuss the state of the field, putative ligands of TREM proteins and the challenges that remain in understanding TREM biology.
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