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News and Views
Nature Immunology - 7, 1288 - 1290 (2006)
doi:10.1038/ni1206-1288

Turning up the heat on HEVs

Shannon K Bromley & Andrew D Luster

Shannon K. Bromley and Andrew D. Luster are with the Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA. luster.andrew@mgh.harvard.edu

Fever is a beneficial systemic response to infection. Such a thermal increase triggers enhanced lymph node recruitment of lymphocytes by augmenting high endothelial venule expression of the homing molecules ICAM-1 and CCL21.

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