Integrins and ITAMs: more than just good neighbors
Mark L Kahn & Gary A Koretzky
Mark L. Kahn is in the Department of Medicine, and Gary A. Koretzky is in the Department of Pathology and Laboratory Medicine and the Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA. koretzky@mail.med.upenn.edu
New data show that integrin signaling by the Syk tyrosine kinase requires adaptors, such as DAP12, that have immunoreceptor tyrosine-based activation motifs.
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