Fetal thymocyte development: putting a zinc finger on it?
Andrea C Carpenter & Craig H Bassing
Andrea C. Carpenter and Craig H. Bassing are in the Immunology Graduate Group and the Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104. bassing@mail.med.upenn.edu
Lymphocyte development must be tightly regulated in utero to prevent rejection. New work shows that the zinc finger protein Zfp608 negatively regulates the expression of recombination-activating genes 1 and 2 and may suppress fetal T cell development.
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