 | Figure 1
Nature Immunology
- 7, 1143 - 1149 (2006)
Published online: 19 October 2006; | doi:10.1038/ni1404
Maintenance and modulation of T cell polarityMatthew F Krummel & Ian Macara | | | | Figure 1. Five polarity systems in motile T lymphocytes.
(a,b) Polarity can be described from the perspective of the actomyosin cytoskeleton (a) or tubulin cytoskeleton (b), which are polarized relative to the direction of migration (green arrow). (c) A front-to-back 'footprint' of integrins on substrates (red shading) and uropodal accumulation of receptors further delineates the polarity. (d) Both directional migration and the associated cycling of integrins require the movement of material through the cytoplasm by means of an endocytic-exocytic loop. (e) Evidence places evolutionarily conserved polarity proteins in distinct locales during migration.
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