Nature Immunology
- 7, 1143 - 1149 (2006)
Published online: 19 October 2006; | doi:10.1038/ni1404
Maintenance and modulation of T cell polarityMatthew F Krummel1 & Ian Macara21
Department of Pathology, University of California at San Francisco, San Francisco, California 94143-0511, USA. 2
Center for Cell Signaling, Department of Microbiology, University of Virginia School of Medicine, Charlottesville, Virginia 22908-0577, USA.
Correspondence should be addressed to Matthew F Krummel matthew.krummel@ucsf.edu or Ian Macara igm9c@virginia.edu As T cells move through the lymphatics and tissues, chemokine receptors, adhesion molecules, costimulatory molecules and antigen receptors engage their ligands in the microenvironment and contribute to establishing and maintaining cell polarity. Cytoskeletal assemblies, surface proteins and vesicle traffic are essential components of polarity and probably stabilize the activity of lymphocytes that must negotiate their 'noisy' environment. An additional component of polarity is a family of polarity proteins in T cells that includes Dlg, Scrib and Lgl, as well as a complex of partitioning-defective proteins. Ultimately, the strength of a T cell response may rely on correct T cell polarization. Therefore, loss of polarity regulators or guidance cues may interfere with T cell activation.
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