Nature Immunology
- 7, 1200 - 1208 (2006)
Published online: 24 September 2006; | doi:10.1038/ni1390
Regulation of effector T cells by antigen-presenting cells via interaction of the C-type lectin MGL with CD45
Sandra J van Vliet, Sonja I Gringhuis, Teunis B H Geijtenbeek & Yvette van Kooyk
Department of Molecular Cell Biology & Immunology, Vrije University Medical Center, Amsterdam, The Netherlands.
Correspondence should be addressed to Yvette van Kooyk y.vankooyk@vumc.nl
Homeostatic control of T cells involves tight regulation of effector T cells to prevent excessive activation that can cause tissue damage and autoimmunity. Little is known, however, about whether antigen-presenting cells (APCs) are also involved in maintaining immune system homeostasis once effector T cells are stimulated. Here we found that immature APCs downregulated effector T cell function by a mechanism involving the C-type lectin MGL expressed by APCs. Glycosylation-dependent interactions of MGL with CD45 on effector T cells negatively regulated T cell receptor–mediated signaling and T cell–dependent cytokine responses, which in turn decreased T cell proliferation and increased T cell death. Thus, regulation of effector T cells by MGL expressed on APCs may provide a target for regulating chronic inflammatory and autoimmune diseases.
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