Christopher E. Rudd is with the Cell Signalling Section, Department of Pathology, Cambridge University, Cambridge CB2 1QP, UK. cer51@cam.ac.uk
A pathway has been defined linking cell cycle inhibitor p27Kip1 to the inhibition of cyclin-dependent kinase 2 and its phosphorylation of transcription factor Smad3 in the induction of in vivo tolerance.
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