Learning from the lost: new insights into TCR specificity
Nathan J Felix & Paul M Allen
Nathan J. Felix and Paul M. Allen are in the Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri 63110 USA. pallen@wustl.edu
Contacts between T cell receptors and peptide–major histocompatibility complex molecules require specific amino acid interactions. However, some amino acids have no direct involvement in contact but nevertheless are critical for specificity.
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