Nature Immunology
- 7, 1066 - 1073 (2006)
Published online: 17 September 2006; | doi:10.1038/ni1386
Virulence factors of Yersinia pestis are overcome by a strong lipopolysaccharide responseSara W Montminy, Naseema Khan, Sara McGrath, Mitchell J Walkowicz, Fiona Sharp, Joseph E Conlon, Koichi Fukase, Shoichi Kusumoto, Charles Sweet, Kensuke Miyake, Shizuo Akira, Robert J Cotter, Jon D Goguen & Egil Lien Supplementary Fig. 1 (pdf 76K)
Y. pestis grown at 37 °C is a poor stimulator of TLR4 signaling. Supplementary Fig. 2 (pdf 52K)
Y. pestis 37 °C LPS inhibits activation of non-human primate cells by 26 °C LPS. Supplementary Fig. 3 (pdf 468K)
Mass spectrometry analysis of lipid A from Y. pestis KIM5 and KIM5-pLpxL grown at 26 °C or 37 °C. Supplementary Fig. 4 (pdf 68K)
Non-human primate cells respond to LPS from Y. pestis KIM5-pLpxL grown at both 26 °C and 37 °C. Supplementary Fig. 5 (pdf 136K)
Y. pestis containing pLpxL retains key features. Supplementary Fig. 6 (pdf 52K)
The presence of plasmid vector does not affect KIM1001 virulence. Supplementary Fig. 7 (pdf 60K)
Y. pestis KIM1001-pLpxL IV infection is associated with increased survivial times. Supplementary Fig. 8 (pdf 72K)
Y. pestis and Y. pestis-pLpxL generate a rough form of LPS. Supplementary Methods (pdf 92K) Supplementary Note (pdf 92K)
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