Nature Immunology
- 7, 1101 - 1108 (2006)
Published online: 10 September 2006; Corrected online: 29 September 2006 | doi:10.1038/ni1384
There is a Corrigendum (November 2006) associated with this Article.
Surface-bound chemokines capture and prime T cells for synapse formationRachel S Friedman, Jordan Jacobelli & Matthew F Krummel
The Department of Pathology, University of California at San Francisco, San Francisco, California 94143, USA.
Correspondence should be addressed to Matthew F Krummel matthew.krummel@ucsf.edu T cell activation in vivo occurs in a lymphoid milieu that presents chemotactic and T cell receptor signals concurrently. Here we demonstrate that T cell zone chemokines such as CCL21 are bound to the surface of lymph node dendritic cells. Contact with antigen-presenting cells bearing chemokines costimulated T cells by a previously unknown two-step contact mechanism. T cells initially formed an antigen-independent 'tethered' adhesion on chemokine-bearing antigen-presenting cells. The formation of those tethers superseded T cell receptor signaling and immunological synapse formation. However, chemokine-tethered T cells were hyper-responsive to subsequent contacts with antigen-presenting cells. Thus, T cells are costimulated 'in trans' and sequentially after initial engagement with their chemokine-rich environment.
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