Luke A.J. O'Neill is in the School of Biochemistry and Immunology, Trinity College, Dublin, Ireland. laoneill@tcd.ie
Toll-like receptor (TLR) signaling must be tightly regulated to avoid uncontrolled inflammation. A fifth Toll–interleukin 1 receptor adaptor domain, SARM, has been identified as an inhibitor of TLR3 and TLR4 signaling.
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