Nature Immunology
- 7, 1021 - 1023 (2006)
doi:10.1038/ni1006-1021
Hematopoietic stem cell biology: too much of a Wnt thingJennifer J Trowbridge1, Randall T Moon2 & Mickie Bhatia11
McMaster Stem Cell and Cancer Research Institute, Hamilton, Ontario L9G 4L6, Canada, and Department of Biochemistry, McMaster University, Hamilton, Ontario, Canada. 2
Howard Hughes Medical Institute, Department of Pharmacology and Institute for Stem Cell and Regenerative Medicine, University of Washington School of Medicine, Seattle, Washington 98195, USA. mbhatia@mcmaster.ca
Wnt signaling has been shown to be involved in stem cell regulation and may represent a key pathway in controlling hematopoiesis. But is it possible for hematopoietic stem cells to get too much of a good thing?
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