Nature Immunology 7, 25 - 32 (2006)
Published online: 15 December 2005; | doi:10.1038/ni1295
Lymphocyte calcium signaling from membrane to nucleusElena M Gallo1, Kirsten Canté-Barrett2
& Gerald R Crabtree1, 21
Program in Immunology, Stanford University, Stanford, California 94305, USA. 2
Howard Hughes Medical Institute and the Departments of Pathology and of Developmental Biology, Stanford University, Stanford, California 94305, USA.
Correspondence should be addressed to Gerald R Crabtree crabtree@stanford.edu Ca2+ signals control a variety of lymphocyte responses, ranging from short-term cytoskeletal modifications to long-term changes in gene expression. The identification of molecules and channels that modulate Ca2+ entry into T and B lymphocytes has both provided details of the molecular events leading to immune responses and raised controversy. Here we review studies of the pathways that allow Ca2+ entry, the function of Ca2+ in the regulation of cell polarity and motility and the principles by which Ca2+-dependent transcription regulates lymphocyte function.
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