Nature Immunology
6, 928 - 937 (2005)
Published online: 14 August 2005; | doi:10.1038/ni1239
Sustained localized expression of ligand for the activating NKG2D receptor impairs natural cytotoxicity in vivo and reduces tumor immunosurveillanceDavid E Oppenheim, Scott J Roberts, Sarah L Clarke, Renata Filler, Julie M Lewis, Robert E Tigelaar, Michael Girardi
& Adrian C Hayday Supplementary Fig. 1 (pdf 3M) Generating Rae-1 transgenic mice. Supplementary Fig. 2 (pdf 4M) Rae-1 transgene expression in lymphocyte populations Supplementary Fig. 3 (pdf 5M) Specific loss of NKG2D staining in Rae-1 transgenic mice. Supplementary Fig. 4 (pdf 7M) Rae-1 is sufficient to drive NKG2D downregulation in vitro. Supplementary Fig. 5 (pdf 2M) In vivo natural cytotoxicity to Rae-1 targets is dependent on NK cells but not  T cells. Supplementary Fig. 6 (pdf 2M) HY-specific CD8 memory T cell cytotoxicity in Rae-1 transgenic mice.
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