Journal home
Advance online publication
Current issue
Archive
Press releases
Focuses
Guide to authors
Online submissionOnline submission
For referees
Free online issue
Contact the journal
Subscribe
Advertising
work@npg
Reprints and permissions
About this site
For librarians
Article
Nature Immunology  6, 928 - 937 (2005)
Published online: 14 August 2005; | doi:10.1038/ni1239

Sustained localized expression of ligand for the activating NKG2D receptor impairs natural cytotoxicity in vivo and reduces tumor immunosurveillance

David E Oppenheim, Scott J Roberts, Sarah L Clarke, Renata Filler, Julie M Lewis, Robert E Tigelaar, Michael Girardi & Adrian C Hayday

Supplementary Fig. 1 (pdf 3M)
Generating Rae-1 transgenic mice.

Supplementary Fig. 2 (pdf 4M)
Rae-1 transgene expression in lymphocyte populations

Supplementary Fig. 3 (pdf 5M)
Specific loss of NKG2D staining in Rae-1 transgenic mice.

Supplementary Fig. 4 (pdf 7M)
Rae-1 is sufficient to drive NKG2D downregulation in vitro.

Supplementary Fig. 5 (pdf 2M)
In vivo natural cytotoxicity to Rae-1 targets is dependent on NK cells but not alphabeta T cells.

Supplementary Fig. 6 (pdf 2M)
HY-specific CD8 memory T cell cytotoxicity in Rae-1 transgenic mice.


 Top
SUPPLEMENTARY INFO
Back to article
Table of contents
Download plugins

Open Innovation Challenges

naturejobs

natureproducts

Search buyers guide:

 
Nature Immunology
ISSN: 1529-2908
EISSN: 1529-2916
Journal home | Advance online publication | Current issue | Archive | Press releases | Focuses | For authors | Online submission | Permissions | For referees | Free online issue | About the journal | Contact the journal | Subscribe | Advertising | work@npg | naturereprints | About this site | For librarians
Nature Publishing Group, publisher of Nature, and other science journals and reference works©2005 Nature Publishing Group | Privacy policy