Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

A CAPRIciously translocating Rac adaptor

Fcγ receptor–mediated phagocytosis requires Rac and Cdc42 GTPases. New data show that CAPRI, a GTPase-activating protein for Ras, functions as an adaptor for Rac and Cdc42 during phagocytosis and early phases of bacterial immunity.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Hypothetical model of CAPRI's participation in Rac activation during FcγR signaling.

Katie Ris

References

  1. Cox, D. et al. J. Exp. Med. 186, 1487–1494 (1997).

    Article  CAS  Google Scholar 

  2. Lockyer, P.J., Kupzig, S. & Cullen, P.J. Curr. Biol. 11, 981–986 (2001).

    Article  CAS  Google Scholar 

  3. Zhang, J., Guo, J., Dzhagalov, I. & He, Y.-W. Nat. Immunol. 6, 911–919 (2005).

    Article  CAS  Google Scholar 

  4. Patel, J.C., Hall, A. & Caron, E. Mol. Biol. Cell 13, 1215–1226 (2002).

    Article  CAS  Google Scholar 

  5. Rossman, K.L., Der, C.J. & Sondek, J. Nat. Rev. Mol. Cell. Biol. 6, 167–180 (2005).

    Article  CAS  Google Scholar 

  6. Liu, Q. et al. J. Cell Biol. 170, 183–190 (2005).

    Article  CAS  Google Scholar 

  7. Minagawa, T., Fukuda, M. & Mikoshiba, K. Biochem. Biophys. Res. Commun. 288, 87–90 (2001).

    Article  CAS  Google Scholar 

  8. Scott, C.C. et al. J. Cell Biol. 169, 139–149 (2005).

    Article  CAS  Google Scholar 

  9. Di Virgilio, F., Meyer, B.C., Greenberg, S. & Silverstein, S.C. J. Cell Biol. 106, 657–666 (1988).

    Article  CAS  Google Scholar 

  10. Park, D.J., Min, H.K. & Rhee, S.G. J. Biol. Chem. 267, 1496–1501 (1992).

    CAS  Google Scholar 

  11. Wen, R., Jou, S.T., Chen, Y., Hoffmeyer, A. & Wang, D. J. Immunol. 169, 6743–6752 (2002).

    Article  CAS  Google Scholar 

  12. Dermardirossian, C. & Bokoch, G.M. Trends Cell Biol. 15, 356–363 (2005).

    Article  CAS  Google Scholar 

  13. Scheffzek, K., Stephan, I., Jensen, O.N., Illenberger, D. & Gierschik, P. Nat. Struct. Biol. 7, 122–126 (2000).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Greenberg, S. A CAPRIciously translocating Rac adaptor. Nat Immunol 6, 864–866 (2005). https://doi.org/10.1038/ni0905-864

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/ni0905-864

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing