Nature Immunology
6, 895 - 901 (2005)
Published online: 14 August 2005; | doi:10.1038/ni1240
Chemokine receptor CCR7 guides T cell exit from peripheral tissues and entry into afferent lymphaticsShannon K Bromley, Seddon Y Thomas
& Andrew D Luster
Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA.
Correspondence should be addressed to Andrew D Luster luster.andrew@mgh.harvard.edu T cell circulation between peripheral tissues and the lymphoid compartment is critical for immunosurveillance and host defense. However, the factors that determine whether T cells remain in peripheral tissue or return to the circulation are undefined. Here we demonstrate that the chemokine receptor CCR7 is a critical signal that determines T cell exit from peripheral tissue. Both CCR7- and CCR7+ effector T cells entered mouse asthmatic lung and while CCR7- T cells accumulated, CCR7+ T cells continued to migrate into afferent lymph. Delivery of both CCR7+ and CCR7- T cells directly into the airways showed that only CCR7+ T cells exited the lung and entered draining lymph nodes. Our study establishes a molecular basis for T cell exit from peripheral tissues.
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