Nature Immunology
6, 889 - 894 (2005)
Published online: 14 August 2005; | doi:10.1038/ni1238
Chemokine receptor CCR7 required for T lymphocyte exit from peripheral tissuesGudrun F Debes1, 2, Carrie N Arnold1, 2, Alan J Young3, Stefan Krautwald4, Martin Lipp5, John B Hay6
& Eugene C Butcher1, 21
Department of Pathology, Stanford University School of Medicine, Stanford University, Stanford, California 94305, USA. 2
Center for Molecular Biology and Medicine, Veterans Affairs Palo Alto Health Care System, Palo Alto, California 94304, USA. 3
Center for Infectious Disease Research and Vaccinology, South Dakota State University, Brookings, South Dakota 57007, USA. 4
Department of Nephrology and Hypertension, University of Schleswig-Holstein, Campus Kiel, Kiel 24105, Germany. 5
Department of Tumor Genetics and Immunogenetics, Max-Delbrück Center for Molecular Medicine, Berlin 13125, Germany. 6
Department of Immunology, Faculty of Medicine, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
Correspondence should be addressed to Gudrun F Debes debes@stanford.edu Lymphocytes travel throughout the body to carry out immune surveillance and participate in inflammatory reactions. Their path takes them from blood through tissues into lymph and back to blood. Molecules that control lymphocyte recruitment into extralymphoid tissues are well characterized, but exit is assumed to be random. Here, we showed that lymphocyte emigration from the skin was regulated and was sensitive to pertussis toxin. CD4+ lymphocytes emigrated more efficiently than CD8+ or B lymphocytes. T lymphocytes in the afferent lymph expressed functional chemokine receptor CCR7, and CCR7 was required for T lymphocyte exit from the skin. The regulated expression of CCR7 by tissue T lymphocytes may control their exit, acting with recruitment mechanisms to regulate lymphocyte transit and accumulation during immune surveillance and inflammation.
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