Nature Immunology
6, 946 - 953 (2005)
Published online: 7 August 2005; | doi:10.1038/ni1237
The Jak-STAT signaling pathway is required but not sufficient for the antiviral response of drosophilaCatherine Dostert1, Emmanuelle Jouanguy1, 2, Phil Irving1, Laurent Troxler1, Delphine Galiana-Arnoux1, Charles Hetru1, Jules A Hoffmann1
& Jean-Luc Imler11
Centre National de la Recherche Scientifique UPR9022, Institut de Biologie Moléculaire et Cellulaire, 67000
Strasbourg, France. 2
Present address: Institut National de la Santé et de la Recherche Médicale U550, Faculté Necker, 75015
Paris, France.
Correspondence should be addressed to Jean-Luc Imler jl.imler@ibmc.u-strasbg.fr The response of drosophila to bacterial and fungal infections involves two signaling pathways, Toll and Imd, which both activate members of the transcription factor NF- B family. Here we have studied the global transcriptional response of flies to infection with drosophila C virus. Viral infection induced a set of genes distinct from those regulated by the Toll or Imd pathways and triggered a signal transducer and activator of transcription (STAT) DNA-binding activity. Genetic experiments showed that the Jak kinase Hopscotch was involved in the control of the viral load in infected flies and was required but not sufficient for the induction of some virus-regulated genes. Our results indicate that in addition to Toll and Imd, a third, evolutionary conserved innate immunity pathway functions in drosophila and counters viral infection.
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