Nature Immunology
6, 749 - 750 (2005)
doi:10.1038/ni0805-749
'TaiLoRing' the response of dendritic cells to pathogensBernard Malissen
& Jonathan J Ewbank
Bernard Malissen and Jonathan J. Ewbank are at the Centre d'Immunologie de Marseille-Luminy, Institut National de la Santé et de la Recherche Médicale−Centre National de la Recherche Scientifique−Université de la Méditerranée, Parc Scientifique de Luminy, Case 906, 13288 Marseille Cedex 9, France. bernardm@ciml.univ-mrs.fr
Cells of the innate and adaptive immune systems often require signals emanating from diverse cell surface receptors for full activation. For dendritic cells, synergistic stimulation by different pairs of Toll-like receptors provides the host with a mechanism to react rapidly and specifically to different pathogens.
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