Hypermutation of antibody-producing B cells occurs in germinal centers, but how autoimmunity from the generation of potentially self-reactive antibodies is avoided has remained puzzling. Characterization of a new mouse mutant, sanroque, indicates previously unknown tolerance mechanisms act at this stage.
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Heissmeyer, V., Ansel, K. & Rao, A. A plague of autoantibodies. Nat Immunol 6, 642–643 (2005). https://doi.org/10.1038/ni1214
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DOI: https://doi.org/10.1038/ni1214