Nature Immunology6, 642 - 643 (2005)
Published online: 29 May 2005; | doi:10.1038/ni1214
A plague of autoantibodies
Vigo Heissmeyer, K Mark Ansel
& Anjana Rao
Vigo Heissmeyer, K. Mark Ansel and Anjana Rao are with the Department of Pathology, Harvard Medical School and the CBR Institute for Biomedical Research, Boston, Massachusetts 02115, USA. arao@cbr.med.harvard.edu
Hypermutation of antibody-producing B cells occurs in germinal centers, but how autoimmunity from the generation of potentially self-reactive antibodies is avoided has remained puzzling. Characterization of a new mouse mutant, sanroque, indicates previously unknown tolerance mechanisms act at this stage.
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